Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 21;8(3):487–511. doi: 10.1016/j.jcmgh.2019.06.005

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Ductal deletion of Hnf1b leads to enhanced signaling pathways that favor tumorigenesis. (A) RT-qPCR of YAP transcriptional targets. (B–E) CTGF (brown) immunohistochemistry. A strong ectopic CTGF staining was observed in (C’) acinar cells in mutants in (D’) the epithelium of metaplastic ducts and (E’) in PanIN. (F) RT-qPCR of the Notch pathway. (G and H) HEY2 immunohistochemistry. (I) RT-qPCR of TGF-β1. (J and K) Phospho-SMAD2 (Ser465, Ser467) immunohistochemistry. (L) RT-qPCR of EGFR. (M and N) Phospho-AKT (Ser473) immunohistochemistry. Nuclei were counterstained with hematoxylin. Scale bars: 100 μm. Control, n ≥ 3; mutant, n ≥ 3 for immunohistochemistry; and control, n = 6; mutant, n = 5 for RT-qPCR. *P < .05; **P < .01; ***P < .001.