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. 2019 Jun 21;8(3):487–511. doi: 10.1016/j.jcmgh.2019.06.005

Figure 9.

Figure 9

Adult Hnf1b inactivation in ductal cells does not lead to obvious perturbation of acinar homeostasis. (A–F) Tamoxifen was injected in 6-week-old adult mice and analyses were performed at (A and B) 2 months or (C–F) 5 months. (A) Mouse weight, pancreas weight, and relative pancreas weight/body weight of 2-month-old mice. (B) RT-qPCR of acinar markers at 2 months. (C) Mouse weight, pancreas weight, and relative pancreas weight/body weight of 5-month-old mice. (D) RT-qPCR of acinar markers at 5 months. (E and F) H&E staining of the pancreata at 5 months. Scale bars: 100 μm. Control, n ≥ 5; mutants, n ≥ 5. *P < .05. CPA, Carboxypeptidase A.