Fig. 1. Presence of tactile allodynia in experimental autoimmune cystitis (EAC) mice and pain-alleviating effect of low-energy shock wave (LESW) treatment. Mechanical stimulation with von Frey filaments of increasing size on the suprapubic region resulted in significantly greater tactile sensitivity in the EAC mouse model than in uninjected mice (A–E). Fifty percent threshold forces were significantly decreased after uroplakin 3A (UPK3A) immunization (F). LESW treatment of UPK3A-immunized mice significantly alleviated the local pain and increased 50% threshold forces (A–F). *p<0.05 compared to Sham. #p<0.05 compared to UPK3A.
