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. 2019 Aug 30;11(13):1625–1643. doi: 10.4155/fmc-2018-0591

Table 1. . Phosphonate prodrugs and nomenclature.

Symmetrical diesters
  R’ =  
Alkyl -(CH2)nCH3 graphic file with name fmc-11-1625-T1a.gif
Aryl -C6H5  
Benzyl -CH2C6H5  
Acyloxyalkyl (POM) -CH2OC(O)C(CH3)3  
Alkoxycarbonyloxyalkyl (POC) -CH2OC(O)OCH(CH3)2  
S-Acylthioalkyl (SATE) -CH2CH2SC(O)R  
Asymmetrical diesters
CycloSal   graphic file with name fmc-11-1625-T1b.gif
HepDirect   graphic file with name fmc-11-1625-T1c.gif
Monoesters
Internal monoester   graphic file with name fmc-11-1625-T1d.gif
Lipid conjugates   graphic file with name fmc-11-1625-T1e.gif
Disulfide lipid conjugates   graphic file with name fmc-11-1625-T1f.gif
Symmetrical bisamidates
Amino acid esters   graphic file with name fmc-11-1625-T1g.gif
Mixed amidate/ester    
ProTides   graphic file with name fmc-11-1625-T1h.gif