Table 1. . Phosphonate prodrugs and nomenclature.
Symmetrical diesters | ||
---|---|---|
R’ = | ||
Alkyl | -(CH2)nCH3 | |
Aryl | -C6H5 | |
Benzyl | -CH2C6H5 | |
Acyloxyalkyl (POM) | -CH2OC(O)C(CH3)3 | |
Alkoxycarbonyloxyalkyl (POC) | -CH2OC(O)OCH(CH3)2 | |
S-Acylthioalkyl (SATE) | -CH2CH2SC(O)R | |
Asymmetrical diesters | ||
CycloSal | ||
HepDirect | ||
Monoesters | ||
Internal monoester | ||
Lipid conjugates | ||
Disulfide lipid conjugates | ||
Symmetrical bisamidates | ||
Amino acid esters | ||
Mixed amidate/ester | ||
ProTides |