Table 4.
Murine leukemia virus (MuLV) induced AML models: Major gene discoveries and their involvement in different French–American–British (FAB) AML subtypes.
| MuLV Virus | Mouse Strain | AML Subtype | FAB Classification | Major Gene Discoveries | References |
|---|---|---|---|---|---|
| CasBrM-MuLV | NFS | Granulocytic | M1 or M2 | His-1 | [235,236] |
| CasBrE MuLV | NIH Swiss | Myeloid | M1 or M2 | Fli-1 | [237,238,239] |
| Endogenous ecotropic MuLV | AKXD-23 | Granulocytic | M1 or M2 | Evi-1 | [240,241] |
| Friend-MuLV | C57BL/6 | Granulocytic | M1 or M2 | Ccnd1 | [237,242,243] |
| Friend-MuLV | DBA/2 | Myeloblastic | M1 or M2 | Evi-1, & c-myb | [244,245,246] |
| M-MuLV | BALB/c | Promonocytic | M5 | c-myb | [246,247] |
| B ecotropic MuLV | BXH-2 | Myelomonocytic | M4 | c-myb, HOXa7, HOXa9, Meis1, CBFa1, SOX4, Hhex, Rarg, Sharp1, Ccnd3, Cdc25l, RASGRP, Clabp, Hmgcr, Nf1, & Il17r | [248,249,250,251,252,253,254,255] |