Table 4.
Inhibitory effects of compounds 2 to 7 on superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils at 10 μM.
| Compounds | Superoxide Anion | Elastase Release | ||||
|---|---|---|---|---|---|---|
| IC50 (μM) a | Inh % b | IC50 (μM) a | Inh % b | |||
| 2 | >10 | 24.46 ± 6.99 | * | >10 | 29.96 ± 6.14 | ** |
| 3 | >10 | 8.88 ± 3.33 | >10 | 27.18 ± 4.05 | ** | |
| 4 | >10 | 3.29 ± 0.88 | * | >10 | 14.43 ± 3.75 | * |
| 5 | >10 | 8.89 ± 4.28 | >10 | 14.89 ± 3.62 | * | |
| 6 | >10 | 4.73 ± 1.53 | * | >10 | 3.09 ± 3.88 | |
| 7 | >10 | 11.95 ± 2.53 | ** | 7.22 ± 0.85 | 59.66 ± 0.83 | *** |
| Idelalisib | 0.07 ± 0.01 | 102.8 ± 2.2 | *** | 0.3 ± 0.1 | 99.6 ± 4.2 | *** |
a Concentration necessary for 50% inhibition (IC50). b Percentage of inhibition (Inh %) at 10 μM. Results are shown as mean ± S.E.M. (n = 3–4). * p < 0.05, ** p < 0.01, *** p < 0.001 compared with the control value.