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. 2019 Aug 20;11(8):1371. doi: 10.3390/polym11081371

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Poly(lactic-co-glycolic acid) polyethylene glycol (PLGA-PEG) nanoparticles, demonstrating greater mucin binding, employing lower density PEG coating compared to higher density, which decreases adhesion on the surface of mucin of the polymeric system (a). In vitro evaluation of PLGA-PEG nanoparticles, illustrating rapid diffusion in mucus ex vivo (b). Comparative analysis of commercial Loteprednol etabonate (LE) suspension eye drops to the polymeric delivery system in a New Zealand White (NZW) rabbit model, with almost 3-times greater Cmax profiles in rabbit aqueous humor, cornea and conjunctiva (c) (Reprinted with permission from [77]).