Table 1.
Gene ontology and pathway enrichment analysis of differentially expressed genes function in pancreatic cancer (top 5 in each category).
| Category | Term | Count | p-Value | Genes |
|---|---|---|---|---|
| BP | GO:0016477 ~ cell migration | 10 | 6.34 × 106 | JUP, STYK1, SDC1, TSPAN1, FAT1, PRKCI, THBS1, SDC4, CEACAM1, ADAM9 |
| BP | GO:0007155 ~ cell adhesion | 13 | 1.89 × 104 | EFNB2, FERMT1, ITGA2, JUP, LGALS3BP, LAMB3, LAMA3, FAT1, MSLN, LAMC2, THBS1, CEACAM1, ADAM9 |
| BP | GO:0098609 ~ cell-cell adhesion | 9 | 1.06 × 103 | PKM, FLRT3, S100P, RPL14, CAPG, ANLN, SFN, GPRC5A, CEACAM1 |
| BP | GO:0022617 ~ extracellular matrix disassembly | 5 | 2.63 × 103 | LAMB3, LAMA3, ADAM10, CAPG, LAMC2 |
| BP | GO:0031581 ~ hemidesmosome assembly | 3 | 3.56 × 103 | LAMB3, LAMA3, LAMC2 |
| CC | GO:0070062 ~ extracellular exosome | 46 | 1.35 × 107 | S100A6, TSPO, FXYD3, SLC44A1, TSPAN1, RPL14, MAL2, MARCKSL1, MLPH, SFN, SDC4, GPRC5A, ZG16B, PKM, LGALS3BP, FAT1, CEACAM5, NQO1, THBS1, MYOF, CEACAM1, DLG1, ADAM9, S100P, ADAM10, SLC12A2, LGALS3, TMC5, PRKCI, SLC6A14, S100A10, S100A14, ANXA3, LCN2, JUP, MTMR11, SDC1, KRT19, TNFSF10, LAMA3, C1ORF116, SERPINB5, CAPG, CTSE, SLPI, AOC1 |
| CC | GO:0005886 ~ plasma membrane | 52 | 3.79 × 105 | SLC44A1, TSPAN1, MARCKSL1, SDC4, PKM, MGLL, CEACAM1, DLG1, NET1, ADAM10, EFNB2, F8, PRKCI, JUP, STYK1, KRT19, SDC1, EFNA5, AOC1, MELK, TNFRSF21, FXYD3, CLDN18, ASAP2, GPRC5A, FAT1, MSLN, AHNAK2, MYOF, FLRT3, KLF5, OSBPL3, SLC12A2, LGALS3, KLB, MET, SLC6A14, ITGA2, DGKH, ITPR3, KCNK1, DOCK5, S100A14, ANXA3, CLDN23, GJB2, KCNN4, P2RX1, PON2, SYTL2, RHBDL2, IFI6 |
| CC | GO:0005923 ~ bicellular tight junction | 7 | 1.87 × 104 | CLDN18, EPPK1, PRKCI, ECT2, AOC1, CLDN23, DLG1 |
| CC | GO:0005925 ~ focal adhesion | 11 | 6.35 × 104 | FLRT3, JUP, SDC1, ADAM10, FAT1, EFNB2, FERMT1, FHL2, ITGA2, SDC4, ADAM9 |
| CC | GO:0005913 ~ cell-cell adherens junction | 9 | 2.70 × 103 | PKM, JUP, S100P, RPL14, CAPG, ANLN, SFN, GPRC5A, DLG1 |
| MF | GO:0043236 ~ laminin binding | 4 | 7.91 × 104 | LGALS3, ITGA2, THBS1, ADAM9 |
| MF | GO:0042803 ~ protein homodimerization activity | 15 | 9.42 × 104 | FLRT3, S100A6, ADAM10, S100A10, ECT2, JUP, LCN2, CTSE, MGLL, CEACAM5, AOC1, AGR2, TOP2A, CEACAM1, MTUS2 |
| MF | GO:0019903 ~ protein phosphatase binding | 5 | 1.18 × 103 | JUP, KCNN4, NEK2, MET, CEACAM1 |
| MF | GO:0098641 ~ cadherin binding involved in cell-cell adhesion | 9 | 1.35 × 103 | PKM, JUP, S100P, RPL14, CAPG, ANLN, SFN, GPRC5A, DLG1 |
| MF | GO:0005509 ~ calcium ion binding | 13 | 6.50 × 103 | S100A6, S100P, CAPN8, S100A10, MMP28, ITPR3, S100A14, ANXA3, FAT1, SYTL2, THBS1, AOC1, MELK |
| KEGG | hsa04512: ECM-receptor interaction | 7 | 5.33 × 103 | SDC1, LAMB3, LAMA3, ITGA2, LAMC2, THBS1, SDC4 |
| KEGG | hsa05205: Proteoglycans in cancer | 6 | 1.93 × 102 | SDC1, MET, ITGA2, THBS1, SDC4, ITPR3 |
| KEGG | hsa04510: Focal adhesion | 6 | 2.17 × 102 | LAMB3, LAMA3, MET, ITGA2, LAMC2, THBS1 |
| KEGG | hsa00512: Mucin type O-Glycan biosynthesis | 3 | 2.41 × 102 | GALNT5, C1GALT1, ST6GALNAC1 |
| KEGG | hsa04151: PI3K-Akt signaling pathway | 7 | 5.10 × 102 | LAMB3, LAMA3, MET, ITGA2, EFNA5, LAMC2, THBS1 |
Note: BP, biological process; CC, cell component; MF, molecular function; GO, gene ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes (as ranked by the p-value).