Table 2.
The hub genes were analyzed by different topological algorithms in the protein–protein interaction network.
| Topological Algorithm | Top 30 Genes Were Ranked by Score |
|---|---|
| Degree | TOP2A, THBS1, NEK2, DLG1, ITGA2, MELK, CEP55, ANLN, ECT2, DTL, SDC1, MET, LAMB3, LAMA3, SDC4, PLD1, EFNB2, DGKH, LAMC2, LGALS3, EFNA5, JUP, KRT19, CEACAM5, LGALS3BP, PKM, SGPP2, ADAM10, HS3ST1, MBOAT2 |
| Edge Percolated Component | TOP2A, MELK, NEK2, ANLN, DTL, CEP55, ECT2, DLG1, MET, SDC1, THBS1, ITGA2, JUP, SDC4, LAMB3, LAMA3, PKM, EFNA5, LAMC2, KRT19, ADAM10, EFNB2, LGALS3BP, HS3ST1, CEACAM5, PLD1, F8, LGALS3, SLC12A2, PRKCI |
| Maximum Neighborhood Component | TOP2A, NEK2, MELK, CEP55, ANLN, ECT2, DTL, ITGA2, LAMB3, THBS1, SDC1, LAMC2, LAMA3, SDC4, DLG1, PKM, DGKH, EFNA5, MET, JUP, HS3ST1, PLD1, MBOAT2, F8, EFNB2, LGALS3BP, PGM2L1, SDR16C5, PRKCI, FHL2 |
| Density of Maximum Neighborhood Component | CEP55, ANLN, ECT2, DTL, NEK2, MELK, LAMC2, LAMA3, TOP2A, LAMB3, ITGA2, SDC4, DLG1, PKM, DGKH, EFNA5, MET, JUP, HS3ST1, PLD1, MBOAT2, F8, EFNB2, LGALS3BP, THBS1, SDC1, PGM2L1, SDR16C5, PRKCI, FHL2 |
| Clustering Coefficient | PKM, CEP55, ANLN, LAMC2, ECT2, DTL, HS3ST1, MBOAT2, F8, NEK2, MELK, LAMB3, LAMA3, DGKH, EFNA5, SDC4, JUP, LGALS3BP, SDC1, ITGA2, TOP2A, THBS1, PLD1, EFNB2, MET, DLG1, PGM2L1, SDR16C5, PRKCI, FHL2 |
| Maximal Clique Centrality | TOP2A, NEK2, MELK, CEP55, ANLN, ECT2, DTL, ITGA2, THBS1, DLG1, TNFSF10, LAMB3, LAMA3, SDC1, OAS1, IFI6, IFI27, LAMC2, MET, SDC4, PLD1, EFNB2, DGKH, LGALS3, JUP, KRT19, CEACAM5, EFNA5, LGALS3BP, GALNT5 |
| Bottleneck | MET, DLG1, TOP2A, SDC1, KRT19, PLD1, MELK, THBS1, LGALS3, ITGA2, EFNB2, DGKH, SGPP2, SDC4, JUP, S100A6, CEACAM5, LCN2, PKM, CEP55, ANLN, PGM2L1, SDR16C5, PRKCI, LAMB3, LAMC2, ECT2, LAMA3, DTL, NEK2 |
| EcCentricity | MET, DLG1, PRKCI, SDC1, TOP2A, EFNA5, ADAM10, JUP, STYK1, KRT19, EFNB2, MELK, PKM, CEP55, ANLN, PGM2L1, SDR16C5, ECT2, THBS1, DTL, NEK2, LGALS3, SLC12A2, RHBDL2, SDC4, FAT1, HS3ST1, PLD1, FOXQ1, ITGA2 |
| Closeness | TOP2A, DLG1, MET, MELK, SDC1, THBS1, ITGA2, NEK2, JUP, CEP55, ANLN, ECT2, DTL, PLD1, KRT19, EFNB2, SDC4, EFNA5, CEACAM5, ADAM10, PKM, LAMB3, LGALS3, PGM2L1, SDR16C5, SLC12A2, PRKCI, STYK1, LGALS3BP, LAMA3 |
| Radiality | MET, DLG1, TOP2A, SDC1, MELK, KRT19, JUP, EFNB2, EFNA5, THBS1, ADAM10, ITGA2, PRKCI, STYK1, PLD1, CEACAM5, SDC4, NEK2, CEP55, ANLN, ECT2, DTL, LGALS3, PKM, PGM2L1, SDR16C5, SLC12A2, HS3ST1, FAT1, LAMB3 |
| Stress | MET, DLG1, TOP2A, SDC1, THBS1, PLD1, KRT19, ITGA2, LGALS3, MELK, EFNB2, CEACAM5, S100A6, LCN2, SDC4, LGALS3BP, JUP, DGKH, SGPP2, ADAM10, EFNA5, LAMB3, LAMA3, NEK2, PKM, CEP55, ANLN, PGM2L1, SDR16C5, PRKCI |
| Betweenness | MET, DLG1, TOP2A, SDC1, PLD1, THBS1, KRT19, ITGA2, LGALS3, EFNB2, MELK, CEACAM5, DGKH, SGPP2, JUP, S100A6, LCN2, LGALS3BP, SDC4, EFNA5, ADAM10, LAMB3, LAMA3, NEK2, PKM, CEP55, ANLN, PGM2L1, SDR16C5, PRKCI |
| Common genes of 12 topological algorithms | MET, MELK, SDC1, THBS1, TOP2A |