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. 2019 Jul 24;8(8):1096. doi: 10.3390/jcm8081096

Figure 3.

Figure 3

Planned dosing scheme during EE-TP treatment phase. All patients will receive infusions at Dose Level 1 for the first 2 treatment cycles (Treatment Cycles 1 and 2). If metabolic correction is not achieved, the subsequent 2 treatment cycles (Treatment Cycles 3 and 4) will be administered at Dose Level 2. If metabolic correction is not achieved, treatment will advance to Dose Level 3 in Treatment Cycles 5 and 6. If metabolic correction is not achieved after Treatment Cycle 6 at Dose Level 3, the Independent Data Monitoring Committee (IDMC) will provide recommendations on the need for dosing modifications.