Table 4.
Serum levels of inflammatory biomarkers *.
| n † | PaO2/FIO2 ≤ 240 n = 171 |
n † | PaO2/FIO2 > 240 n = 84 |
p Value | |
|---|---|---|---|---|---|
| C-reactive protein day 1, mg/dL | 164 | 13 (6–21) | 81 | 11 (4–19) | 0.13 |
| C-reactive protein day 3, mg/dL | 149 | 11 (4–19) | 78 | 9 (5–15) | 0.078 |
| IL-6 day 1, pg/mL | 89 | 168 (72–431) | 36 | 109 (41–229) | 0.077 |
| IL-6 day 3, pg/mL | 75 | 91 (19–204) | 32 | 78 (33–183) | 0.98 |
| IL-8 day 1, pg/mL | 89 | 108 (64–214) | 36 | 94 (57–137) | 0.17 |
| IL-8 day 3, pg/mL | 75 | 76 (41–145) | 32 | 99 (63–170) | 0.15 |
| TNF-alpha day 1, pg/mL | 89 | 8 (5–17) | 36 | 7 (5–14) | 0.73 |
| TNF-alpha day 3, pg/mL | 75 | 7 (4–14) | 32 | 8 (5–15) | 0.61 |
| Procalcitonin day 1, ng/mL | 90 | 0.45 (0.14–1.37) | 37 | 0.19 (0.07–0.59) | 0.037 |
| Procalcitonin day 3, ng/mL | 78 | 0.30 (0.10–1.06) | 34 | 0.20 (0.08–0.74) | 0.57 |
| MR-proADM day 1, nmol/L | 98 | 1.27 (0.33–2.22) | 40 | 1.16 (0.65–2.23) | 0.84 |
| MR-proADM day 3, nmol/L | 87 | 1.36 (0.38–2.37) | 37 | 1.08 (0.61–2.04) | 0.92 |
* Results are given as median (inter-quartile range). † Number of cases with blood samples processed for each inflammatory biomarker and group. Definition of abbreviations: IL: interleukin; TNF: tumor necrosis factor; MR-proADM: mid-regional pro-adrenomedullin.