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. 2019 Aug 2;9(8):336. doi: 10.3390/biom9080336

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Concentration-dependent activation of the DAU-induced second component of the ASIC1a current. (a) Representative whole-cell traces for currents evoked by a fast pH 5.5 stimulus in the control (black) and in the channels that were pre-incubated for 15 s with DAU at various concentrations (red). (b) The dose–response curve fitted to the logistic equation for the second component of the ASIC1a current. I/I_max is the amplitude of the second component of the current at a conditioning pH of 7.8, normalized to the maximum amplitude (I_max) calculated for each oocyte by individual fitting. Data are presented as mean ± SEM (n = 6).