Figure 3.

Tripartite model of gp41 N-terminal heptad repeats (NHR) with side view and C-terminal heptad repeats (CHR)-derived peptides. Above, the sequences of CHR-peptides targeting NHR. Residues represent pocket-binding domain and lipid- binding domain marked in blue and orange, respectively. Below, residues of CHR are divided into three groups: major binding sites α, assistant binding sites β, and non-binding sites γ. The potential interaction, or interaction, between CHR and NHR is shown in blue or red dashed lines.