Table 2.
Top 10 single-nucleotide polymorphisms (SNPs) in the genes related to vitamin D metabolism and transcriptional activity associated with season-adjusted 25(OH)D concentrations among controls only, the EPIC study, 1992–2003 a.
| Gene b | SNP | N | 25(OH)D, β (95% CI) | P | PBH c |
|---|---|---|---|---|---|
| VDR | rs2239182 | 742 | −3.82 (−6.15, −1.49) | 0.001 | 0.949 |
| LRP2 | rs2673170 | 747 | −4.43 (−7.27, −1.58) | 0.002 | 0.949 |
| NCOA7 | rs579477 | 758 | −3.57 (−6.07, −1.07) | 0.005 | 0.949 |
| GC | rs1352844 | 747 | 5.26 (1.63, 8.88) | 0.005 | 0.949 |
| GC | rs188812 | 752 | 5.38 (1.57, 9.20) | 0.006 | 0.949 |
| GC | rs2298849 | 757 | 4.26 (1.11, 7.41) | 0.008 | 0.949 |
| CUBN | rs4525114 | 750 | 7.11 (1.94, 12.29) | 0.007 | 0.949 |
| CYP27B1 | rs4646536 | 751 | 3.65 (0.93, 6.37) | 0.009 | 0.949 |
| CYP27B1 | rs10877013 | 764 | 3.42 (0.73, 6.12) | 0.013 | 0.974 |
| HDAC9 | rs212669 | 753 | −8.12 (−14.34, −1.90) | 0.011 | 0.974 |
a Adjusted for age at blood collection, sex, and center. b Genes related to vitamin D metabolism and transcriptional activity. c P after Benjamini–Hochberg (BH) multiple testing correction.