Table 5.
Associations of season-adjusted 25(OH)D concentrations (per 24.96 nmol/L) with CRC risk by genotypes, the EPIC study, 1992–2003.
| Gene/SNP | Major Allele Homozygotes | Heterozygotes | Minor Allele Homozygotes | P interaction b | |||
|---|---|---|---|---|---|---|---|
| Cases/Controls | OR (95%CI) a | Cases/Controls | OR (95%CI) a | Cases/Controls | OR (95%CI) a | ||
| Vitamin D metabolism | |||||||
| CYP27B1 rs10877013 | 557/383 | 1.00 (0.86,1.17) | 510/311 | 0.84 (0.73,0.97) | 108/70 | 0.61 (0.40,0.93) | 0.024 |
| CYP27B1 rs4646536 | 551/381 | 1.00 (0.86,1.17) | 485/300 | 0.85 (0.74,0.99) | 110/70 | 0.62 (0.41,0.95) | 0.034 |
| GC rs1352846 | 500/319 | 0.96 (0.81,1.13) | 406/286 | 0.79 (0.67,0.93) | 104/68 | 0.58 (0.35,0.97) | 0.049 |
| GC rs16846876 | 530/331 | 1.05 (0.90,1.23) | 477/337 | 0.75 (0.65,0.88) | 144/81 | 0.88 (0.63,1.21) | 0.017 |
| GC rs2298850 | 584/384 | 1.00 (0.86,1.15) | 445/293 | 0.80 (0.68,0.94) | 86/61 | 0.56 (0.33,0.97) | 0.038 |
| GC rs3755967 | 569/359 | 0.99 (0.85,1.15) | 436/297 | 0.78 (0.66,0.91) | 101/64 | 0.66 (0.40,1.09) | 0.034 |
| GC rs842873 | 261/192 | 0.73 (0.58,0.91) | 588/354 | 0.84 (0.73,0.97) | 240/196 | 1.22 (0.97,1.52) | 0.002 |
| VDR complex/Transcriptional Co-regulators and Co-activators | |||||||
| ARID1A rs11247596 | 720/474 | 0.96 (0.85,1.09) | 400/256 | 0.76 (0.63,0.92) | 53/34 | 0.42 (0.20,0.86) | 0.051 |
| ARID1A rs12737946 | 998/640 | 0.83 (0.74,0.93) | 168/116 | 1.25 (0.95,1.66) | 9/8 | - c | 0.016 |
| ARID1A rs12752833 | 998/641 | 0.83 (0.74,0.93) | 165/114 | 1.22 (0.92,1.62) | 9/8 | - | 0.025 |
| CARM1 rs7254708 | 764/515 | 0.82 (0.73,0.93) | 208/144 | 1.04 (0.81,1.32) | 9/8 | - | 0.0001 |
| CHAF1A rs243341 | 596/403 | 0.78 (0.68,0.90) | 468/276 | 0.95 (0.80,1.13) | 102/78 | 1.42 (0.97,2.07) | 0.020 |
| CHAF1A rs243365 | 607/434 | 0.80 (0.70,0.91) | 408/257 | 1.02 (0.86,1.22) | 50/44 | 1.64 (0.89,3.02) | 0.027 |
| SMARCA2 rs2296212 | 920/607 | 0.81 (0.72,0.91) | 229/142 | 1.15 (0.89,1.48) | 14/7 | 4.09 (0.29,58.01) | 0.035 |
| Inflammation | |||||||
| IL10 rs3024509 | 1015/657 | 0.92 (0.83,1.03) | 132/100 | 0.62 (0.45,0.85) | 3/2 | - | 0.024 |
| IL10 rs6686931 | 747/476 | 0.80 (0.70,0.91) | 373/243 | 1.02 (0.86,1.20) | 49/38 | 1.42 (0.59,3.39) | 0.029 |
a Adjusted for age at blood collection, sex, and center. b Interactions between SNPs and 25(OH)D stratifying by categories of 25(OH)D concentrations and assuming a log-additive model for genetic markers. c Not estimatable due to small sample size.