Table 2.

Known genes associated with skin cutaneous melanoma development, metastasis, and prognosis in the core module network.

Gene Symbol	Full Name	Gene Function	References
ABCF1	ATP binding cassette subfamily F member 1	The protein encoded by this gene is a member of the ATP-binding cassette (ABC) transporters superfamily, and it is involved in the development of SKCM.	[57]
CD9	CD9 molecule	This gene encodes a transmembrane 4 superfamily member whose expression plays a key role in inhibiting the metastasis of SKCM.	[58,59]
EPOR	erythropoietin receptor	The gene encodes an erythropoietin receptor and is a member of the cytokine receptor family. Its dysregulation is associated with metastasis and prognosis of cutaneous melanoma.	[60,61]
EXT1	exostosin glycosyltransferase 1	This gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase. It is associated with the development of SKCM.	[62]
MIA	MIA SH3 domain containing	It is a cartilage-derived retinoic acid-sensitive protein. This gene is associated with metastasis of cutaneous melanoma and is highly sensitive tumor markers for monitoring of patients with SKCM.	[63,64]
PROX1	prospero homeobox 1	The protein encoded by this gene is a member of the homeobox transcription factor family. It is related to the prognosis of SKCM.	[65,66]
RHOJ	ras homolog family member J	This gene encodes a Rho family GTP-binding protein that is involved in the invasion and metastasis of cutaneous melanoma.	[67,68]
SDC1	syndecan 1	The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan, and it is associated with invasion of SKCM.	[69,70]
TBK1	TANK binding kinase 1	The gene is a member of the atypical IκB kinase family and is associated with invasion and migration of SKCM.	[71]
UGDH	UDP-glucose 6-dehydrogenase	The protein encoded by this gene converts UDP-glucose into UDP-glucuronic acid, thereby participating in the biosynthesis of glycosaminoglycans. It is related to the development of SKCM.	[72]