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. 2019 Aug 1;11(8):366. doi: 10.3390/pharmaceutics11080366

Table 3.

Pharmacokinetic parameters of alpinumisoflavone (AIF) after intravenous (i.v.) injection of AIF-loaded mPEG-b-PLA micelles and AIF dissolved in 25% Cremophor EL®/ethanol (EtOH) solution.

Parameters AIF in 25% Cremophor EL®/EtOH Solution AIF-Loaded mPEG-b-PLA Micelle
AUC a (min·μg·mL−1) 326 ± 168 876 ± 103 *
C0 b (μg·mL−1) 1.89 ± 0.63 7.86 ± 1.79
CLt c (mL·kg−1·min) 94.6 ± 56.1 23.1 ± 2.7
Vd d (mL·kg−1) 13903 ± 5274 2940 ± 867
BA e (%) 100 ± 51 269 ± 18 *

a AUC, area under the curve; b C0, plasma concentration at time 0; c CLt, total clearance; d Vd, volume of distribution; BAe, bioavailability, * p < 0.05.