Table 4.
Concordant PIK3CA and TP53 somatic mutations between tumors and ctDNA in primary breast cancer patients.
| Patient ID | Diagnostic Mammography | Markers | Type | Gene | HGVS | SafeSEQ VAF (%) | Protein | Tumor VAF (%) | COSMIC | Chr |
|---|---|---|---|---|---|---|---|---|---|---|
| 13MS | IDC, grade 3 | ER+/HER2+ | Luminal B | TP53 | c.398T > A | 20.56 | p.M133K | 75.2 | COSM11781 | 17 |
| 16MS | IDC, grade 3 | ER+/HER2+ | Luminal B | PIK3CA | c.3140A > T | 3.60 | p.H1047L | 28.2 | COSM776 | 3 |
| 16MS | IDC, grade 3 | ER+/HER2+ | Luminal B | TP53 | c.743G > T | 2.11 | p.R248L | 43.1 | COSM6549 | 17 |
| 44MS | IDC, grade 3 | ER+/HER2+ | Luminal B | TP53 | c.587G > C | 1.03 | p.R196P | 35.8 | COSM43814 | 17 |
| 9MS | IDC, grade 3 | ER-/PR-/HER2- | Triple negative | TP53 | c.637C > T | 0.91 | p.R213Ter | 46.9 | COSM10654 | 17 |
| 67MS | IDC, grade 2 | ER+/HER2− | Luminal A | PIK3CA | c.3145G > C | 0.39 | p.G1049R | 82.4 | COSM12597 | 3 |
| 7MS | IDC, grade 2 | ER+/HER2− | Luminal A | PIK3CA | c.3140A > G | 0.14 | p.H1047R | 31 | COSM775 | 3 |
| 30MS | IDC, grade 2 | ER+/HER2− | Luminal A | PIK3CA | c.1633G > A | 0.05 | p.E545K | 56.2 | COSM763 | 3 |
| 40MS | IDC, grade 1 | ER+/HER2+ | Luminal B | PIK3CA | c.1624G > A | 0.20 | p.E542K | 25.5 | COSM760 | 3 |
IDC: Invasive ductal carcinoma; HGVS: Human Genome Variation Society; SafeSEQ VAF: Plasma variant allele frequency; Tumor VAF: Tumor variant allele frequency; COSMIC: Catalog of somatic mutations in cancer; Chr: Chromosome.