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. 2019 Jul 24;8(8):1088. doi: 10.3390/jcm8081088

Figure 1.

Figure 1

Proposed mechanisms [34] of the accumulation of 18F-fluoromisonidazole (FMISO). In hypoxic conditions, FMISO is reduced (i.e., FMISO obtains electrons) and either becomes amino-FMISO, covalently binds to macromolecules, or is conjugated with glutathione.