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. 2019 Aug 19;9(8):381. doi: 10.3390/biom9080381

Figure 5.

Figure 5

Motor behaviour in the cylinder, rotarod, and adjusted stepping tests before and after 20 µg LPS injection and PBM treatment. (a) Proportion of rears led with the paw contralateral to injection in the cylinder test. There was a significant difference compared to vehicle for both LPS (* p < 0.05) and PBM (## p < 0.01) groups at post-surgery day 3, which persisted for the LPS group at post-surgery day 5 (** p < 0.01). Vehicle: n = 7; LPS: n = 9; PBM: n = 8. (b) Time taken to fall off the rotarod. There was a significant difference between LPS and vehicle groups at both time points (*** p < 0.001 at day 4; ** p < 0.01 at day 6) and between PBM and vehicle at post-surgery day 4 only (## p < 0.01). PBM rats improved on post-surgery day 6 but were not significantly different from LPS rats. Vehicle: n = 7; LPS: n = 9; PBM: n = 9. (c) There was no significant difference between groups in the number of adjusted steps made by rats with the ipsilateral (left) paw in the forehand direction in the adjusted stepping test, nor for the (d) ipsilateral paw backhand direction. (e) In the contralateral (right) paw, forehand direction, there was a significant difference at post-surgery day 4 between LPS and vehicle groups (* p < 0.05) and between PBM and vehicle groups (## p < 0.01), but not between LPS and PBM groups. There were no significant differences at post-surgery day 6. (f) In the contralateral paw backhand direction, there were significant differences in the number of steps between LPS and vehicle groups at post-surgery days 4 and 6 (* p < 0.05) and between PBM and vehicle groups at post-surgery day 4 only (## p < 0.01). (c–f): Vehicle: n = 7; LPS: n = 9; PBM: n = 9. (a–f): Repeated-measures two-way ANOVA with Tukey multiple comparisons test. Values represent baseline-corrected means ± SEM.