Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 13;9(8):362. doi: 10.3390/biom9080362

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Methodological trends in the construction of the compound–target network. (A) The frequencies of databases and tools used to identify targets of herbal ingredients. * databases that provide validated drug-target interactions (DTIs); ** databases that provide validated databases that provide both validated and predicted DTIs; # Computational tools to predict DTIs. (B) A co-occurrence pattern of the DTI method. (C) Categories of DTI methods and their composition. The outer circle and inner circle represent the DTI methods and their categories, respectively. (D) The annual rate of the groups of DTI methods. Note that THM-NP studies in 2011 were excluded from the visualization due to their low frequency (n = 2). TCMSP, Traditional Chinese Medicine Systems Pharmacology Database; TTD, Therapeutic Target Database; SEA, Similarity Ensemble Approach; HIT, Herb Ingredients’ Targets; WES, Weighted Ensemble Similarity.