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. 2019 Sep;189(9):1814–1830. doi: 10.1016/j.ajpath.2019.05.022

Figure 9.

Figure 9

Analysis of RS-HepcKO model at 6 and 12 months in mice. A: Graph of Hepc mRNA levels in neurosensory retina (NSR), measured by real-time quantitative PCR (qPCR), in RS-HepcKO versus controls at 6 months. B: Hepc mRNA levels in retinal pigment epithelium (RPE) of RS-HepcKO versus controls at 6 months. C: Hepc mRNA levels in liver of RS-HepcKO versus controls at 6 months. D: Serum iron concentration of RS-HepcKO mice versus controls at 6 months. E: Serum transferrin saturation of RS-HepcKO mice versus controls at 6 months. F: Graph of Tfrc mRNA levels, measured by qPCR, in NSR of RS-HepcKO versus controls at 6 months. G: Graph of Tfrc mRNA levels, measured by qPCR, in RPE of RS-HepcKO versus controls at 6 months. H: Graph of Dmt1 mRNA levels, measured by qPCR, in NSR of RS-HepcKO versus controls at 6 months. I: Graph of Dmt1 mRNA levels, measured by qPCR, in RPE of RS-HepcKO versus controls at 6 months. J and K:In vivo fundus images and autofluorescence images of 6-month–old RS-HepcKO and control mice. L: VIP-enhanced Perls iron staining of plastic sections of 12-month–old RS-HepcKO retina. M and N:In vivo fundus images and autofluorescence images of 12-month–old RS-HepcKO and control mice. Statistical analysis was performed using two-group, two-sided t-test. ∗P < 0.05, ∗∗∗∗P < 0.0001. Scale bar = 50 μm (L). GCL, ganglion cell layer; INL, inner nuclear layer; IPL, inner plexiform layer; ONL, outer nuclear layer; OPL, outer plexiform layer.