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. 2019 Sep;189(9):1797–1813. doi: 10.1016/j.ajpath.2019.05.021

Figure 1.

Figure 1

Significantly altered metabolites in ileum obtained from sepsis-challenged pigs compared with controls. A: Heat map of significantly altered metabolites using t-test results. B: Pathway enrichment analysis of significantly altered metabolites. Metabolic pathway analysis shows all metabolic pathways arranged according to the scores from enrichment analysis (y axis) and from topology analysis (x axis). C and D: Significantly increased (C) or decreased (D) metabolite peak signal in sepsis-challenged ileum compared with vehicle-control ileum. n = 9 control ileum samples (C and D); n = 13 septic ileum samples (C and D). ∗P < 0.05 versus control, false-discovery rate (FDR) < 0.33; †linoleic acid metabolism, P = 7.9 × 10−4, FDR = 0.02 (metabolites: linoleic acid and phosphatidylcholine); ‡valine, leucine, and isoleucine biosynthesis, P = 4.2 × 10−3, FDR = 0.08 (metabolites: l-leucine and l-valine); §phenylalanine, tyrosine, and tryptophan biosynthesis, P = 0.3.69 × 10−2, FDR = 0.59 (metabolites: phenylalanine).