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. 2019 Sep;189(9):1797–1813. doi: 10.1016/j.ajpath.2019.05.021

Figure 2.

Figure 2

Significantly altered metabolites in jejunum obtained from sepsis-challenged pigs compared with controls. A: Heat map of significantly altered metabolites using t-test significant metabolites. B: Pathway enrichment analysis of significantly altered metabolites. Metabolic pathway analysis shows all metabolic pathways arranged according to the scores from enrichment analysis (y axis) and from topology analysis (x axis). C and D: Significantly increased (C) or decreased (D) metabolite peak signal in sepsis-challenged jejunum compared with vehicle-control jejunum. n = 9 control jejunum samples (C and D); n = 13 septic jejunum samples (C and D). ∗P < 0.05 versus control, false-discovery rate (FDR) < 0.38; †arginine and proline metabolism, P = 3.5904 × 10−4, FDR = 0.02 (metabolites: hydroxyproline, spermidine, fumaric acid, and urea); ‡citric acid cycle, P = 5.1567 × 10−4, FDR = 0.02 (metabolites: succinic acid, malic acid, and fumaric acid); §phenylalanine, tyrosine, and tryptophan biosynthesis, P = 0.03, FDR = 0.39 (metabolite: phenylalanine).