Table 1.
Amino acid mutations in the hemagglutinin (HA) of escape mutants derived from A/chicken/Jiangsu/XZ299/2016/H9N2 (XZ299).
| MAb | HI Titers (log2) a | Mutations | ||||
|---|---|---|---|---|---|---|
| XZ299 | Mutants | m3F2 | rgPR8-H9 166N | rgPR8-H9 166D | ||
| 2G10 | 10 | 3 (m2G10-1) | 4 | 9 | 1 | Q133L/D207N/N218D/L234M b |
| - (m2G10-2) | Q133L/A168D/D207N/N218D | |||||
| 3F2 | 7 | 1 (m3F2) | 1 | 10 | - | N166D |
| 5C7 | 10 | 5 (m5C7) | 10 | / c | / | Q133L/N167K/D207N/N218D |
a Shown are the titers with each MAb; -, no detected inhibition in hemagglutination inhibition (HI) assay. b Amino acid mutations are numbered according to the H9 number. c Not test.