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. 2019 Aug 28;9:724. doi: 10.3389/fonc.2019.00724

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Copyright © 2019 Pei, Zheng, She, Fang, Zhang, Hu, Xu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Whether PSMP in serum and urine from PCa patients could be used as a diagnostic biomarker PCa compared with PSA was confirmed in another set of collected samples. (A–C) Total PSA, free PSA, and total/free PSA in serum from the BPH group, medium Gleason score group, and high Gleason score group were measured and analyzed. (D) Sensitivity and specificity of total/free PSA as a diagnostic biomarker were analyzed by an ROC curve. (E,F) Serum and urine PSMP levels in the BPH group, medium Gleason score group, and high Gleason score group were measured and analyzed. (G,H) Sensitivity and specificity of serum and urine PSMP as diagnostic biomarkers were analyzed by ROC curves.