| A. Choice of Model: | Which of the different NCI models should be implemented? |
| B. Covariates: | Which covariates should be included in the model? |
| C. Stratification versus Pooling: | Should age/sex groups be pooled to provide more precise estimates? |
| D. Outliers: | How should outliers be identified and when should they be removed? |
| E. Computational Time: | What is the computational time required by the NCI method? |