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. 2019 Aug 6;9(8):348. doi: 10.3390/biom9080348

Figure 2.

Figure 2

High glucose-derived microparticles (MPs; 10 µg/mL) induce phosphorylation of two downstream targets of the mammalian target of rapamycin (mTOR) pathway in naïve renal proximal tubular cells. (A) Representative Western blots of P-4E-BP1 and P-p70S6K; and (B,C) densitometry analyses of P-4E-BP1 and P-p70S6K levels normalized to β-actin respectively. Values were expressed as mean ± SEM; n = 3; * p < 0.05 versus no MPs (control); # p < 0.05 versus control MPs; P-4E-BP1: Phosphorylated-eukaryotic translation initiation factor 4E-binding protein 1; P-p70S6K: Phosphorylated-70kD ribosomal protein S6 kinase; iHG: Intermittent high glucose; cHG: Continuous high glucose.