Table 2.
Immunoreactivity of cytokines, chemokines, remodelling factors, regulatory factors, and antimicrobial peptides in the COPD group by semi-quantitative grading. Summary of median values and interquartile ranges.
| COPD (N = 40) | ||||||
|---|---|---|---|---|---|---|
| Bronchial Epithelium | Bronchial Mucosal Connective Tissue | Bronchial Mucosal Blood Vessel Wall | Bronchial Smooth Muscle | Bronchial Glands | Bronchial Cartilage | |
| Mdn (Q2) IQR |
||||||
| IL-1α | ++/+++ | +/++ | + | 0/+ | + | ++/+++ |
| 1.5 | 1.5 | 1.5 | 0.5 | 1.0 | ||
| IL-4 | +++ | ++ | ++ | + | +/++ | ++ |
| 1.5 | 1.5 | 1.5 | 1.0 | 1.0 | ||
| IL-6 | ++ | 0/+ | + | 0/+ | 0/+ | + |
| 2.0 | 1.0 | 1.0 | 0 | 1.0 | ||
| IL-7 | +++/++++ | ++/+++ | ++/+++ | +/++ | ++ | |
| 1.5 | 1.5 | 1.5 | 1.5 | 2.0 | ||
| IL-8 | +++ | ++ | ++ | + | +/++ | |
| 2.0 | 1.0 | 1.5 | 1.0 | 1.75 | ||
| IL-10 | +++ | ++/+++ | ++/+++ | +/++ | +/++ | |
| 2.0 | 1.5 | 1.5 | 1.5 | 2.0 | ||
| IL-12 | ++/+++ | ++/+++ | ++ | + | + | |
| 1.5 | 1.0 | 1.5 | 0.5 | 0.5 | ||
| TNF-α | ++ | ++ | ++ | + | + | +++ |
| 1.0 | 1.5 | 1.5 | 0.5 | 1.5 | ||
| MMP-2 | ++/+++ | ++ | +/++ | 0/+ | + | ++ |
| 1.5 | 2.0 | 1.5 | 1.0 | 1.0 | ||
| TIMP-2 | +++ | ++ | +/++ | +/++ | + | ++ |
| 2.0 | 1.5 | 1.5 | 2.0 | 1.5 | ||
| TGF-β1 | ++/+++ | ++/+++ | ++/+++ | +/++ | + | |
| 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | ||
| Hsp-70 | 0 | 0 | 0 | 0 | 0 | + |
| 0.5 | 0.5 | 2.0 | 0 | 0.5 | ||
| hBD-2 | +/++ | ++ | ++ | + | + | ++/+++ |
| 1.5 | 2.0 | 1.5 | 1.0 | 0.5 | ||
| hBD-3 | ++ | ++ | +/++ | 0/+ | + | +/++ |
| 1.5 | 1.0 | 1.0 | 0.5 | 0.5 | ||
| hBD-4 | 0/+ | 0/+ | 0/+ | 0 | 0 | +/++ |
| 1.0 | 1.0 | 0.5 | 0 | 0.25 | ||
Semi-quantitative grading scores are displayed with rank values. “Control”– Control group, “N”–Number of the study subjects, “Mdn”– Median value, “IQR”– interquartile range (with 95% CI–95% Confidence interval), “Q2”– 2nd Quartile (50th percentile value).