Table 4.
Genus | Treatment | Composition of Bacterial Genus (%) * | ||
---|---|---|---|---|
Baseline | 24 Weeks | Change | ||
Bifidobacterium † | CP2305 | 9.8 ± 1.8 | 6.1 ± 1.3 | −3.6 ± 1.2 |
Placebo | 14.7 ± 2.6 | 6.8 ± 1.3 | −7.9 ± 2.3 | |
Faecalibacterium | CP2305 | 10.5 ± 1.8 | 16.5 ± 2.0 | 6.0 ± 1.4 |
Placebo | 6.8 ± 1.0 | 12.4 ± 1.9 | 5.6 ± 1.7 | |
Roseburia | CP2305 | 4.5 ± 1.2 | 4.7 ± 1.0 | 0.2 ± 1.2 |
Placebo | 2.8 ± 0.6 | 6.6 ± 1.5 | 3.7 ± 1.4 | |
Streptococcus † | CP2305 | 1.8 ± 0.7 | 1.6 ± 0.6 | −0.2 ± 0.3 |
Placebo | 1.3 ± 0.4 | 1.8 ± 0.5 | 0.5 ± 0.6 | |
Dorea | CP2305 | 1.5 ± 0.2 | 1.8 ± 0.3 | 0.3 ± 0.3 |
Placebo | 1.7 ± 0.2 | 1.9 ± 0.4 | 0.2 ± 0.4 | |
Lachnospiraceae; Other † | CP2305 | 2.1 ± 0.4 | 1.6 ± 0.3 | −0.5 ± 0.2 |
Placebo | 1.4 ± 0.3 | 1.4 ± 0.2 | 0.0 ± 0.2 | |
Ruminococcus | CP2305 | 1.7 ± 0.4 | 2.9 ± 0.6 | 1.2 ± 0.7 |
Placebo | 1.2 ± 0.3 | 2.8 ± 0.8 | 1.6 ± 0.8 |
* Data are presented as the mean ± SEM. † Significant differences between CP2305 and placebo groups (p < 0.05) by ANCOVA with each initial value as a covariate. Partial eta squared values of Bifidobacterium, Streptococcus, and Lachnospiraceae; Other are 0.096, 0.152, and 0.158, respectively.