Table 1.
Baseline demographics and clinical characteristics. Data are presented as no. (%) or mean ± standard deviation. Abbreviations: BMI, body mass index; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma glutamyl transferase; HCC, hepatocellular carcinoma; INR, international normalized ratio.
| Variable | n/Mean |
|---|---|
| Demographic Factors (n = 271) | |
| Age (years) | 59.29 ± 10.5 |
| Sex | 183 (66.8%) men / 91 (33.2%) woman |
| BMI (kg/m2) | Overall = 26.48 ± 4.21 − Normal (<25 kg/m2) n = 114 (41.6%) − Overweight (≥25 to <30 kg/m2) n = 109 (39.8%) − Obese (≥30 kg/m2) n = 51 (18.6%) |
| Metabolic Syndrome | n = 43 (17.3%) |
| Noninvasive Measures | |
| LSM (n = 271) | Mean: 12.79 kPa ± 10.7; F1 = 69 (25.2%) F2 = 59 (21.5%) F3 = 44 (16.1%) F4 = 102 (37.5%) |
| CAP (dB/m) (n = 25) | 223.04 ± 85.7 |
| NAFLD fibrosis score (n = 271) | −1.27 ± 1.34 |
| FIB4 (n = 271) | 3.75 ± 12.2 |
| HEPAMET score (n = 271) | 0.12 ± 3.94 |
| APRI (n = 271) | 1.59 ± 3.94 |
| FORNS (n = 271) | 6.82 ± 1.95 |
| Medical History (n = 271) | |
| Diabetes Mellitus | n = 36 (13.1%) − Diet n = 3 (1%) − OHAs n = 18 (6.5%) − Insulin n = 15 (5.4%) |
| Hypertension | n = 83 (30.2%) |
| Dislypemia | n = 45 (16.4%) – Diet 15 (5.4%) − Statins 10 (3.6%) |
| Psiquiatric Disorder | n = 55 (20%) – anxiety n = 45 (16.4%) – Psychotic disorder n = 10 (3.6% ) |
| Toxics | Drugs n = 136 (49.6%); ExPWID n = 98 ( 35.7%); Tobacco n = 208 (75.9%) |
| Coffee | n = 173 (63.1%) |
| Child Pugh Score (A/B/C) | n = 92 (33.57%)/n = 10 (3.6%)/n = 0 |
| Varices/Ascites/ Encephalopaty/HCC | n = 21 (7.7%)/n = 5 (1,8%) /n = 2 (0.7%)/ n = 3 (1.1) |
| Serum Biochemical Levels (n = 271) | |
| ALT, UI/mL | 84.20 ± 66.97 |
| AST, UI/mL | 66.19 ± 51.725 |
| GGT, UI/mL | 88.28 ± 125.92 |
| Bilirrubin, mg/dL | 1.13 ± 4.51 |
| Albumin, mg/dL | 4.30 ± 0.34 |
| Fasting Glucose Levels, mg/dL | 92.96 ± 28.1 |
| Insulin, µU/mL | 11.11 ± 6.31 |
| HOMA | 2.56 ± 2.256 |
| Platelets Count, 10*3/µL | 174.12 ± 64.82 |
| International normalized ratio (INR) | 2.19 ± 10.13 |
| Triglycerides, mg/dL | 99.39 ± 45.38 |
| Total Cholesterol, mg/dL | 166.51 ± 39.12 |
| High-Density Lipoprotein, mg/dL | 51.34 ± 15.6 |
| Low-Density Lipoprotein, mg/dL | 96.44 ± 31.16 |