Table 4.
Randomized clinical trials of BoNT/A for low back pain and osteoarthritic pain.
| Pain Condition | Number of Participants | Dose and Delivery Route | Primary Outcome | Reference | |
|---|---|---|---|---|---|
| low back pain | 31 | 40 U/site 200 U i.m. |
% of responders (50% reduction in pain rating) | BoNT/A 73.3% placebo 25% |
[149] |
| refractory shoulder pain | 36 | 100 U i.a. | pain rating 0–10 | BoNT/A -2.4 placebo -0.8 |
[150] |
| refractory painful total knee arthroplasty | 54 | 100 U i.a. | % of responders (2-point reduction in pain ratings) | BoNT/A 71% placebo 35% |
[151] |
| knee osteoarthritis | 176 | 200 U or 400 U i.a. |
pain rating 0–10 | BoNT/A 200 U -1.6 BoNT/A 400U -2.1 placebo -2.1 |
[152] |
| knee osteoarthritis | 121 | 200 U i.a. | pain rating 0–10 | BoNT/A -2.2 placebo -2.5 |
[153,154] |
i.m. intramuscular, i.a. intraarticular.