Table 1.

Inclusion and exclusion criteria.

Main inclusion criteria	(1) Men and women with age older than 20 years
	(2) Individuals with skin dryness
	(3) Written informed consent for participation in the trial
Main exclusion criteria	(1) Severe skin allergy, such as urticaria
	(2) Secondary infection with bacteria, fungi, or virus
	(3) Uncontrolled hypertension (SBP > 145 mmHg or DBP > 95 mmHg)
	(4) Severe liver disability (2.5-fold the normal high range value for ALT, AST)
	(5) Severe renal disability (sCr > 2.0 mg/dL)
	(6) Women who are pregnant, lactating, planning a pregnancy or women of child-bearing age who do not agree to use proper contraception
	(7) Use of oral steroids, oral antibiotic or other immunosuppressants within the past 4 weeks
	(8) Treated by systemic photochemotherapy within the past 4 weeks
	(9) History of drug abuse
	(10) Hypersensitivity to isoflavone
	(11) Use of other investigational products within the past two months
	(12) History of psychiatry disorders
	(13) History of severe immunocompromise