Figure 3.

Effects of HWMF and LMWF on NK cell cytotoxic activity in NK-92MI cells. NK cells were incubated with the indicated concentrations of HMWF and LMWF for 24 h. After incubation, NK cells were co-incubated with YAC-1 cells, as target cells, in effector-to-target ratios of 2:1, 10:1, and 50:1 for 4 h. NK cytotoxic activity was measured by lactate dehydrogenase (LDH) assay. Values are presented as mean ± standard deviation (n = 3). Different letters indicate significant differences from the CON group at p < 0.05 by Tukey’s post-hoc test. CON: control; ConA: concanavalin A; HMWF: high molecular weight fucoidan; LMWF: low molecular weight fucoidan.