Effects of HWMF on cytokine mRNA expression in CY-treated mice. Immunosuppression was induced by injection of CY (100 mg/kg/d, i.p.) on day 21. (A–I) Graphic representation of mRNA expression levels of cytokines, interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ, respectively. The CY-treated only (CY only) group was orally administered alone from day 1 to day 28, while HMWF-treated groups, HWMF low group, and HMWF high group, were administered HWMF at a dosage of 25 and 75 mg/kg b.w., respectively. Values are presented as mean ± standard deviation (n = 6). Different letters indicate significant differences from the CY only group at p < 0.05 by a Duncan test.