Figure 1.

Osteoarthritis (OA) and osteoporosis (OP). OA and OP are two major silent rheumatic diseases with specific features, and are included in the World Health Organization (WHO) disease-disabling lists. Nevertheless, they clearly present different clinical diagnoses and development. OA is highly associated to cartilage degradation and OP is associated to bone mineral density (BMD) alterations. Interestingly, both diseases not only manifest unique risk factors, but also shared ones. Among the shared risk factors stand inflammation and metabolic alterations. Interestingly, both shared risk factors are associated to visfatin, a life-essential adipokine.