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. 2019 Aug 19;8(8):1251. doi: 10.3390/jcm8081251

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Waterfall plot illustrating the PSA response to first and second line androgen signaling inhibitors (ASIs). Dotted lines express the level of >50% PSA decline. In the first-line treatment, PSA decline of more than 50% from the baseline is observed in 59.3% (54 of 92) for abiraterone and 67% (60 of 92) for enzalutamide, with no significant difference (Chi-square: p = 0.28). In the second-line treatment, PSA decline of more than 50% from the initiation of second-line treatment is significantly less observed in abiraterone as a second line (8.3%) compared with enzalutamide following abiraterone (26.7%) (Chi-square: p = 0.03). PSA response from the baseline at each line is shown in the right panel.