Table 3.

Multivariate analysis adjusting with putative variables for the prediction of TTPP and rPFS from the initiation of second line treatment.

	TTPP at 2nd Line				Radiographic PFS
Variables	HR	95%CI		p Value	HR	95%CI		p Value
Treatment sequence
Abi to Enz	Ref				Ref
Enz to Abi	1.791	1.091	3.163	0.043	1.538	0.855	3.019	0.219
Visceral mets at 2nd line treatment
No
Yes	3.647	1.003	23.634	0.049	3.647	1.182	19.278	0.032
LN mets at 2nd line treatment
No	Ref				Ref
Yes	1.663	0.847	3.406	0.141	1.233	0.784	2.392	0.221
Bone mets at 2nd line treatment
No	Ref				Ref
Yes	1.946	0.972	4.071	0.06	1.392	0.872	4.281	0.099
PSA decline ≥50% at first line
No	Ref				Ref
Yes	0.641	0.401	0.933	0.038	0.865	0.431	1.283	0.492
ECOG-PS
0	Ref				Ref
>1	2.154	1.163	4.154	0.014	1.538	0.699	2.193	0.293

TTPP: time to PSA progression, HR: hazard ratio, CI: confidential interval, ECOG-PS: Eastern Cooperative Oncology Group performance status