Table 1.
The subfamilies of the ABCF family, and the numbers (N) of phyla and species in which they are encoded
| Subfamily | N Phyla | N Species | Notes on function, relationships and taxonomic distribution |
|---|---|---|---|
| YdiF | 42 | 1852 | Broad distribution in bacteria; polyphyletic |
| Uupa | 24 | 3104 | Broad distribution in bacteria; paraphyletic to EttA. Inc. P resistance TaeA [38] |
| EttA | 18 | 2337 | Broad distribution in bacteria; translation factor |
| YbiT | 15 | 1874 | Broad distribution in bacteria; potential translation factor |
| BAF2 | 7 | 305 | Proteobacteria, Planctomycetes, Spirochaetes, Actinobacteria, Bacteroidetes, Gemmatimonadetes, Cyanobacteria |
| ARE1a | 6 | 269 | M, L, S, P, K resistance, inc. VgaA [21], MsrA [18], MsrE [33]; Firmicutes, Actinobacteria, Spirochaetes, Bacteroidetes, Proteobacteria, Tenericutes |
| ARE3a | 5 | 261 | L resistance inc. LsaA [20]; Firmicutes, Spirochaetes, Proteobacteria, Fusobacteria, Actinobacteria |
| DAF1 | 5 | 58 | Spirochaetes, Proteobacteria, Deferribacteres, Fibrobacteres, Chlamydiae |
| YfmM | 5 | 587 | Firmicutes, Tenericutes, Proteobacteria, Fusobacteria, Bacteroidetes |
| YheS | 5 | 1234 | Proteobacteria, Bacteroidetes, Cyanobacteria, Arthropoda, Elusimicrobia |
| BAF3 | 4 | 111 | Bacteroidetes, Proteobacteria, Cyanobacteria, Elusimicrobia |
| DAF2 | 4 | 24 | Proteobacteria, Planctomycetes, Spirochaetes, Omnitrophica |
| ARE2a | 2 | 54 | Antibiotic resistance inc. VmlR [19]; Firmicutes, Tenericutes |
| ARE4a | 2 | 173 | M,M16 resistance inc. CarA [39], SrmB [39], TlrC [39], OleB [23]; Actinobacteria, Chloroflexi |
| ARE5a | 2 | 408 | L,S resistance inc. VarM [26], LmrC [40]; Actinobacteria, Proteobacteria |
| BAF1 | 2 | 20 | Firmicutes, Actinobacteria |
| PAF1 | 1 | 138 | Proteobacteria |
| AAF1 | 1 | 313 | Actinobacteria |
| AAF2 | 1 | 301 | Actinobacteria |
| AAF4 | 1 | 219 | Actinobacteria |
| AAF6 | 1 | 649 | Actinobacteria |
| AAF3 | 1 | 8 | Actinobacteria |
| AAF5 | 1 | 25 | Actinobacteria |
| ARE6a | 1 | 8 | L, S resistance SalA [22]; Firmicutes |
| ARE7a | 1 | 35 | Oxazolidinone resistance OptrA [25], Firmicutes |
| BdAF1 | 1 | 176 | Bacteroidetes |
| DAF3 | 1 | 36 | Proteobacteria |
| FAF1 | 1 | 37 | Firmicutes |
| FAF2 | 1 | 42 | Firmicutes |
| SAF1 | 1 | 66 | Firmicutes |
| ABCF2 | 27 | 560 | Arb1 ribosome biogenesis factor; broadly distributed but lacking in Apicomplexa and Microsporidia |
| ABCF1 | 23 | 376 | ABC50 translation initiation factor; found in plants, diverse algae, and opisthokonts excluding fungi |
| ABCF7 | 16 | 131 | Found in plants, diverse algae, Alveolata, Excavata and Microsporidia |
| ABCF3 | 13 | 382 | Gcn20 starvation response; Opisthokonts |
| eEF3L | 9 | 83 | Diverse algae, Chytridiomycota and choanoflagellates |
| ABCF4 | 7 | 37 | Diverse algae and Filozoa |
| ABCF5 | 7 | 105 | Diverse algae and fungi |
| cpYdiF | 7 | 85 | Diverse algae |
| algAF1 | 6 | 25 | Diverse algae |
| cpEttA | 6 | 18 | Chloroplast targeting peptides predicted; plants and diverse algae |
| algUup | 5 | 17 | Found in diverse algae |
| ABCF6 | 5 | 17 | Found in diverse algae and Amoebozoa |
| mEttA | 3 | 14 | Mitochondrial targeting peptides predicted; diverse algae, Amoebozoa |
| New1 | 3 | 127 | Fungi |
| eEF3 | 2 | 138 | Translation factor; fungi |
Resistance to antibiotic class in notes column is as follows: M, 14- and 15-membered ring macrolides; M16, 16-membered ring macrolides; L, lincosamides; S, streptogramins; K, ketolides; P, pleuromutilins.
a
Subfamilies containing known AREs.