Fig. 5.

Simplified schematics of binding modes of moxifloxacin and QPT-1 in site 1.

Simplified schematic binding modes derived from S. aureus gyrase^CORE crystal structures with DNA [16] are shown for the following: (A) moxifloxacin and (B) QPT-1. In panel B, zoliflodacin, a derivative of QPT-1, is shown faintly (see Supplementary Fig. 1 for chemical structures). Compounds binding in pocket 1 (largely within the DNA—green rectangle) can extend out of the DNA into a broad open pocket on GyrB.