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. 2019 Jul 27;9(8):311. doi: 10.3390/biom9080311

Figure 1.

Figure 1

Simplified representation of ganglioside biosynthesis. Gangliosides are classified in four series according to the number of sialic acid residues linked to lactosylceramide (LacCer) [2]. The 0-series gangliosides are directly synthesized from LacCer and the precursors of other series are synthesized by specific sialyltransferases: ST3Gal V (GM3 synthase), ST8Sia I (GD3 synthase) and ST8Sia V (GT3 synthase), respectively. The elongation of precursors is performed by the sequential action of N-acetyl-galactosaminyltransferase (β4GalNAc T1), galactosyltransferase (β3Gal T4) and sialyltransferases (ST3Gal II and ST8Sia V). Cer, ceramide. Adapted from [6].