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. 2019 Jul 27;9(8):311. doi: 10.3390/biom9080311

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Interactions of gangliosides with growth factor receptors in neuro-ectodermal derived (ND) cancers. (A) Negative regulation of malignant properties of cancers cells through GM1 and GM3 interaction with growth factor receptor. (B) Positive regulation of malignant properties of neuronal cells through interactions of TrkA receptor with GM1 in the presence of NGF (1) or with GD1b and GT1b in the absence of NGF (2) [53].