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. 2019 Aug 20;11(8):1950. doi: 10.3390/nu11081950

Table 2.

Selected studies for systematic review: coeliac disease screening tests and diagnosis, and characteristics of the control group.

First Author CD Screening Tests CD Diagnostic Criteria Control Group
Wilson [17] Anti-reticulin antibodies and biopsy Biopsy when positive ant-reticulin antibodies and response to the GFD No controls
Collin [9] IgA anti-gliadin or IgA anti-reticulin antibodies and biopsy Biopsy when positive anti-gliadin or anti-reticulin antibodies Women with normal obstetric history who had undergone laparoscopic sterilization
Kolho [18] IgA EMA Positive EMA Women personnel without infertility problems (mean number of children 1.5)
Meloni [19] IgA/G anti-gliadin, IgA EMA, total IgA and biopsy Biopsy when positive 2 out of the 3 antibodies Healthy school children from the same geographical area
Vancikova [10] IgA/G anti-gliadin, IgA anti-TG2, IgA EMA and total IgA EMA when positive anti-gliadin or anti-TG2 Healthy blood donors
Fasano [12] IgA/G anti-gliadin, IgA EMA, total IgA, HLA-DQ and biopsy Positive EMA with biopsy or with compatible HLA Female not-at-risk subjects
Shamaly [20] IgA anti-TG2, IgA EMA, total IgA and biopsy Biopsy when positive anti-TG2 or EMA or when IgAD is present Healthy Arab women
Tiboni [14] IgA anti-TG2, IgA EMA and biopsy Biopsy when positive anti-TG2 or EMA Healthy women not reporting reproductive problems with at least one child delivered
Bustos [21] IgA/G anti-gliadin, IgA anti-TG2 and total IgA Positive 2 out of the 3 antibodies Argentine Caucasian women of the blood bank with at least two children and without pregnancy losses
Jackson [22] IgA anti-TG2, IgA EMA and biopsy Positive anti-TG2 and EMA Prevalence in general population of US (0.8%)
Kumar [11] IgA/G anti-gliadin, IgA anti-TG2 and IgA EMA Positive anti-TG2 Women with normal obstetric history
Hogen Esch [23] IgA anti-TG2 and IgA EMA Positive anti-TG2 and EMA Prevalence in general adult female population of The Netherlands
Choi [13] IgA/G anti-gliadin, IgA anti-TG2, IgA EMA, total IgA and biopsy Biopsy when positive anti-TG2 or EMA CD expected in women of similar age in the same geographical area (1.3%)
Khoshbaten [24] IgA/G anti-TG2, total IgA and biopsy Biopsy when positive anti-TG2 Healthy couples lacking reproductive problems with at least one child delivered
Sharshiner [25] IgA/G anti-TG2 and IgA/G EMA Positive anti-TG2 or EMA Healthy women with a history of ≥2 uncomplicated term live births, no more than one pregnancy loss prior week 20, and no major medical or obstetric problems or clinical features of CD
Machado [26] IgA anti-TG2, IgA EMA, total IgA, HLA-DQ and biopsy Biopsy when positive anti-TG2 or EMA Prevalence in blood donors in Brazilian regions (0.2–0.5%)
Karaca [27] IgA/G anti-gliadin, IgA/G anti-TG2, IgA/G EMA, total IgA and biopsy Biopsy when positive anti-gliadin, anti-TG2 or EMA No controls
Sarikaya [28] IgA/G anti-TG2 Positive anti-TG2 Healthy fertile females with no history of RPL with at least two child delivered
Sabzebari [29] IgA/G anti-TG2, total IgA and biopsy Biopsy when positive anti-TG2 No controls
Gunn [30] IgA anti-TG2 and total IgA Positive anti-TG2 No controls
Juneau [31] IgA anti-TG2 and IgA EMA Positive anti-TG2 or EMA No controls
Grode [32] IgA anti-TG2, total IgA (IgG anti-PDG when IgA deficiency) and biopsy Biopsy when positive anti-TG2 or anti-PDG Prevalence of Danish general population (0.48%)
Kutteh [33] IgA anti-TG2, IgA EMA and IgA anti-PDG Positive anti-TG2, EMA or anti-PDG Healthy non-pregnant women with at least one live birth and no miscarriages

TG2: type 2 transglutaminase; EMA: antiendomisium antibodies.