Table 1.
Single nucleotide polymorphisms (SNPs) selected from two-stage genome-wide association study (GWAS).
| 1st Stage (N = 7000) | 2nd Stage (N = 3000) |
Combined (N = 10,000) |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chr | SNP | BP | Gene | Alleles | Beta | P-Value | FDR | Beta | P-Value | Beta | P-Value | F | R2 |
| 4 | rs4148155 | 89054667 | ABCG2 | A/G | 0.31 | 9.35 × 10−46 | 2.86 × 10−40 | 0.32 | 5.60 × 10−22 | 0.31 | 4.34 × 10−66 | 37.7 | 0.022 |
| 4 | rs3733588 | 9997303 | SLC2A9 | A/G | −0.26 | 2.91 × 10−37 | 5.93 × 10−32 | −0.21 | 2.80 × 10−11 | −0.24 | 1.73 × 10−46 | 25.9 | 0.015 |
| 4 | rs2725211 | 88970375 | PKD2 | C/T | 0.25 | 1.86 × 10−25 | 1.14 × 10−20 | 0.30 | 1.50 × 10−17 | 0.27 | 3.18 × 10−41 | 24.2 | 0.014 |
| 4 | rs17013282 | 88765873 | MEPE | G/A | 0.19 | 1.03 × 10−11 | 1.15 × 10−7 | 0.21 | 1.38 × 10−6 | 0.20 | 4.95 × 10−17 | 11.1 | 0.007 |
| 4 | rs17013187 | 88733531 | IBSP | C/T | 0.16 | 1.49 × 10−9 | 1.35 × 10−5 | 0.14 | 6.63 × 10−4 | 0.15 | 2.85 × 10−12 | 8.8 | 0.005 |
| 4 | rs3756224 | 10105739 | WDR1 | T/C | 0.11 | 1.05 × 10−7 | 6.67 × 10−4 | 0.10 | 1.73 × 10−3 | 0.11 | 9.45 × 10−10 | 7.9 | 0.005 |
| 2 | rs1260326 | 27730940 | GCKR | C/T | 0.10 | 7.90 × 10−7 | 4.38 × 10−3 | 0.11 | 6.55 × 10−4 | 0.10 | 2.33 × 10−9 | 8.5 | 0.005 |
| 1 | rs4072037 | 155162067 | MUC1 | T/C | 0.11 | 8.18 × 10−6 | 3.60 × 10−2 | 0.11 | 4.56 × 10−3 | 0.11 | 1.43 × 10−7 | 6.8 | 0.004 |
GWAS with age, sex, BMI, and principle component (PC)1–5 (concerning stratification and batch effects) adjustment. Chr: Chromosome, BP: base pair, Alleles: Major allele/minor allele, FDR: P-value with false discovery rate (FDR) correction, F: F-statistical value.