Table 2.
Sample characteristics by weighted genetic risk score (WGRS) quartile.
| Characteristic | WGRS | P-Value † | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Q1 (N = 2490) | Q2 (N = 2509) | Q3 (N = 2499) | Q4 (N = 2502) | ||||||
| Mean | (SD) | Mean | (SD) | Mean | (SD) | Mean | (SD) | ||
| SUA (mg/dL) | 5.4 | (1.3) | 5.6 | (1.5) | 5.8 | (1.5) | 6.0 | (1.6) | <0.0001 * |
| Sex (Men%) | 49.7% | 49.3% | 52.2% | 48.8% | 0.080 | ||||
| Age (yr) | 49.1 | (11.4) | 48.9 | (11.0) | 48.6 | (11.0) | 48.8 | (11.1) | 0.140 |
| BMI (kg/m2) | 24.2 | (3.6) | 24.3 | (3.6) | 24.3 | (3.6) | 24.3 | (3.6) | 0.570 |
| FG (mg/dL) | 96.6 | (21.6) | 96.0 | (20.7) | 96.4 | (19.1) | 97.4 | (25.0) | 0.136 |
| T-CHO (mg/dL) | 193.4 | (35.9) | 191.8 | (35.1) | 191.9 | (34.1) | 194.1 | (36.6) | 0.060 |
| TG (mg/dL) | 118.0 | (104.0) | 113.8 | (83.0) | 117.9 | (81.9) | 124.7 | (118.3) | 0.002 * |
| HDL-C (mg/dL) | 53.7 | (13.4) | 53.3 | (13.2) | 52.8 | (12.8) | 52.8 | (13.1) | 0.050 |
| LDL-C (mg/dL) | 120.3 | (31.8) | 120.4 | (32.2) | 120.4 | (31.1) | 121.4 | (31.1) | 0.520 |
| eGFR (mL/min/1.73m2) | 103.4 | (24.4) | 102.7 | (24.6) | 102.2 | (24.7) | 102.9 | (25.1) | 0.41 |
| SGOT (U/L) | 24.6 | (16.6) | 24.6 | (12.5) | 24.7 | (13.1) | 24.2 | (10.4) | 0.582 |
| SGPT (U/L) | 24.5 | (18.8) | 25.2 | (21.6) | 25.8 | (23.5) | 24.8 | (19.4) | 0.110 |
| SBP (mmHg) | 115.7 | (16.9) | 116.0 | (17.1) | 116.7 | (17.3) | 116.9 | (18.0) | 0.060 |
| DBP (mmHg) | 71.6 | (10.8) | 72.0 | (10.9) | 72.7 | (11.3) | 72.8 | (11.3) | 0.010 * |
SUA: serum uric acid; BMI: body mass index; FG: fasting glucose; T-CHO: total cholesterol; TG: triglyceride; HDL-C/LDL-C: high-/low-density lipoprotein cholesterol; estimated Glomerular filtration rate; SGOT: serum glutamic-oxalocetic Transaminase; SGPT: serum Glutamic-Pyruvic Transaminase; SBP/DBP: systolic/diastolic blood pressure. *: P < 0.05. †: Chi-square test for categorical variables. Analysis of variance for continuous variables. Variables with skewed distribution were log-transformed before input for analysis. eGFR (mL/min/1.73 m2) = 175 × (Scr)−1.154 × (Age)−0.203 × (0.742 if women) × (1.212 if African-American).