Table 4.
Optimally fitted logistic-GGD location–scale mixture regression models relating cardiovascular disease (CVD) events to sex and the WGRS.
| Predictors | Logistic | Location | Scale | Shape | AIC | ||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% C) | P-Value | EST (95% CI) | P-Value | EST (95% CI) | P-Value | EST (95% CI) | P-Value | ||
| (a) continuous WGRS | |||||||||
| Intercept | 1 | Referent | 4.16 a (4.11, 4.21) | <0.001 | −2.37 a (−3.00, −1.73) | <0.001 | 1.42 a (0.35, 2.49) | 0.009 | 2594.09 |
| Male | 2.87 a (2.01, 4.10) | <0.001 | |||||||
| WGRS | 1.41 c (1.04, 1.91) | 0.029 | |||||||
| (b) four-group WGRS | |||||||||
| Intercept | 1 | Referent | 4.16 a (4.11, 4.21) | <0.001 | −2.37 a (−3.00, −1.73) | <0.001 | 1.42 b (0.35, 2.50) | 0.009 | 2593.36 |
| Male | 2.86 a (2.00, 4.10) | <0.001 | |||||||
| Q2 | 0.94 (0.57, 1.53) | 0.790 | |||||||
| Q3 | 1.46 (0.93, 2.29) | 0.103 | |||||||
| Q4 | 1.68 c (1.08, 2.62) | 0.022 | |||||||
| (c) two-group WGRS | |||||||||
| Intercept | 1 | Referent | 4.16 a (4.11, 4.21) | <0.001 | −2.37 a (−3.00, −1.73) | <0.001 | 1.42 b (0.35, 2.50) | 0.009 | 2589.89 |
| Male | 2.85 a (1.99, 4.07) | <0.001 | |||||||
| High | 1.62 b (1.17, 2.23) | 0.003 | |||||||
AIC: Akaike information criterion, CI: confidence interval, EST: estimated regression coefficient, OR: estimated odds ratio, WGRS: weighted genetic risk score. a P < 0.001, b P < 0.01, and c P < 0.05 for 2-sided P-value of the Wald test.