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. 2019 Aug 15;8(8):1228. doi: 10.3390/jcm8081228

Table 2.

Meta-regression Analysis of Association between Covariates and Risk of Cardiovascular Disease.

Risk of Cardiovascular Disease
Univariate Multivariate
Unadjusted OR (95% CI) p Value I2 (%) R2 (%) Adjusted OR (95% CI) p Value I2 (%) R2 (%)
Sex
 Men 1 (Reference) NA 1 (Reference) NA
 Women 0.77 (0.50; 1.19) 0.23 59.3 0 0.65 (0.46; 0.90) 0.014 59.3 0
Age, per year increase 0.99 (0.97; 1.00) 0.06 60.6 1.6 0.98 (0.97; 1.00) 0.030 39.1 1 28.5 1
Smoke status
 Nonsmoker 1 (Reference) NA 1 (Reference) NA
 Smoker 1.00 (0.99; 1.01) 0.94 65.5 0 1.01 (1.00; 1.02) 0.17 0 2 99.99 2
Follow-up duration, per year increase 1.01 (0.99; 1.03) 0.43 64.5 2.2 1.00 (0.97; 1.02) 0.69 41.1 3 18.1 3

CI, confidence interval; NA, not applicable; OR, odds ratio. Bold font represents statistically significant results. 1 Covariates: female sex and age. 2 Covariates: female sex, age, and smoker 3 Covariates: female sex, age and follow-up duration.