Table 6.

Evaluation of the top ten gene markers through literature evidence, KEGG pathway and Gene Ontology analyses.

Gene	Literature Evidence	KEGG Pathway & Gene Ontology Terms	Status
	(Connected with)
Rps21	Biological functions: artificial nucleic acid molecules [56], exosome and human ribosome biogenesis [57], arterial vasculature [58]	KEGG pathway: Ribosome (p-value = 3.91 $\times {10}^{-62}$), GO:BP: GO:0006412 translation (p-value = 3.83 $\times {10}^{-74}$), GO:CC: GO:0005622 intracellular (p-value = 6.8 $\times {10}^{-3}$), GO:0022627 cytosolic small ribosomal subunit (p-value = 8.99 $\times {10}^{-24}$), GO:MF: GO:0003735 structural constituent of ribosome (p-value = 2.15 $\times {10}^{-56}$), GO:0044822 poly(A) RNA binding (p-value = 5.08 $\times {10}^{-115}$).	Known
Slc5a1	Solute carriers [59]	KEGG pathway: Mineral absorption (p-value = 1.11 $\times {10}^{-4}$), mmu04973: Carbohydrate digestion and absorption (p-value = 9.90 $\times {10}^{-4}$), GO:BP: GO:0006810 transport (p-value = 2.01 $\times {10}^{-3}$), GO:0001951 intestinal D-glucose absorption (p-value = 2.01 $\times {10}^{-2}$), GO:CC: GO:0070062 extracellular exosome (p-value = 3.28 $\times {10}^{-81}$), GO:MF: GO:0015293 symporter activity (p-value = 1.93 $\times {10}^{-2}$).	Known
Crip1	Xenopus laevis embryogenesis [60]	GO:CC: GO:0005737 cytoplasm (p-value = 6.06 $\times {10}^{-31}$), GO:MF: GO:0008301 DNA binding, bending (p-value = 2.11 $\times {10}^{-3}$), GO:0042277 peptide binding (p-value = 4.27 $\times {10}^{-3}$).	Known
Rpl15	Artificial nucleic acid molecules [56]	KEGG pathway: Ribosome (pval=3.91 $\times {10}^{-62}$), GO:BP: GO:0098609 cell-cell adhesion (p-value = 5.06 $\times {10}^{-13}$), GO:0002181 cytoplasmic translation (p-value = 2.91 $\times {10}^{-10}$), GO:CC: GO:0005739 mitochondrion (p-value = 2.25 $\times {10}^{-22}$), GO:0030529 intracellular ribonucleoprotein complex (p-value = 1.35 $\times {10}^{-99}$), GO:0070062 extracellular exosome (p-value = 3.28 $\times {10}^{-81}$), GO:MF: GO:0003735 structural constituent of ribosome (p-value = 2.15 $\times {10}^{-56}$).	Known
Rpl3	Artificial nucleic acid molecules [56]	KEGG pathway: Ribosome (p-value = 3.91 $\times {10}^{-62}$), GO:BP: GO:0002181 cytoplasmic translation (p-value = 2.91 $\times {10}^{-10}$), GO:0042254 ribosome biogenesis (p-value = 1.81 $\times {10}^{-09}$), GO:CC: GO:0070062 extracellular exosome (p-value = 3.28 $\times {10}^{-81}$), GO:0031012 extracellular matrix (p-value = 2.06 $\times {10}^{-11}$), GO:0005761 mitochondrial ribosome (p-value = 2.56 $\times {10}^{-3}$), GO:MF: GO:0003735 structural constituent of ribosome (p-value = 2.15 $\times {10}^{-56}$).	Known
Rpl27a	Arterial vasculature [58]	KEGG pathway: Ribosome (p-value = 3.91 $\times {10}^{-62}$), GO:BP: GO:0006412 translation (p-value = 3.83 $\times {10}^{-74}$), GO:CC: GO:0022626 cytosolic ribosome (p-value = 5.88 $\times {10}^{-5}$), GO:0022625 cytosolic large ribosomal subunit (p-value = 1.34 $\times {10}^{-36}$), GO:MF: GO:0003735 structural constituent of ribosome (p-value = 2.15 $\times {10}^{-56}$).	Known
Rps3a1	-	KEGG pathway: Ribosome (p-value = 3.91 $\times {10}^{-62}$), GO:BP: GO:0006412 translation (p-value = 3.83 $\times {10}^{-74}$), GO:0043066 negative regulation of apoptotic process (p-value = 5.39 $\times {10}^{-5}$), GO:CC: GO:0070062 extracellular exosome (p-value = 3.28 $\times {10}^{-81}$), GO:0022627 cytosolic small ribosomal subunit (p-value = 8.99 $\times {10}^{-24}$), GO:0030529 intracellular ribonucleoprotein complex (p-value = 1.35 $\times {10}^{-99}$), GO:MF: GO:0044822 poly(A) RNA binding (p-value = 5.08 $\times {10}^{-115}$).	Known
Rps17	Different biological functions: proteomic analysis [56,57,58,61]	KEGG pathway: Ribosome (p-value = 3.91 $\times {10}^{-62}$), GO:BP: GO:0000028 ribosomal small subunit assembly (p-value = 1.17 $\times {10}^{-7}$), GO:CC: GO:0070062 extracellular exosome (p-value = 3.28 $\times {10}^{-81}$), GO:0005739 mitochondrion (p-value = 2.25 $\times {10}^{-22}$), GO:0031012 extracellular matrix (p-value = 2.06 $\times {10}^{-11}$), GO:MF: GO:0003735 structural constituent of ribosome (p-value = 2.15 $\times {10}^{-56}$).	Known
Aldob	Hepatocellular cellular carcinoma [62].	-	Known
Khk	-	-	Novel