Table 1.
Descriptive statistics by TSH group.
| Variables | TSH, mIU/L | p Value | |||
|---|---|---|---|---|---|
| <0.03 | 0.03–0.3 | 0.3–2 | 2–5 | ||
| (n = 473) | (n = 394) | (n = 164) | (n = 61) | ||
| Age at surgery, years | 50.6 ± 10 | 51.2 ± 11.2 | 47.6 ± 12 | 47.6 ± 12 | 0.001 |
| Age at follow-up, years | 52.7 ± 10.1 | 53.4 ± 11.2 | 50 ± 11.9 | 50.3 ± 11.8 | 0.002 |
| Follow-up, years | 2.2 ± 0.9 | 2.2 ± 0.9 | 2.3 ± 0.9 | 2.7 ± 1 | <0.001 |
| History of hypertension | 145 (30.7%) | 161 (40.9%) | 48 (29.3%) | 21 (34.4%) | 0.007 |
| History of diabetes | 87 (18.4%) | 79 (20.1%) | 32 (19.5%) | 10 (16.4%) | 0.876 |
| Ever smokers | 26 (5.5%) | 22 (5.6%) | 11 (6.7%) | 5 (8.2%) | 0.805 |
| Preoperative TSH * | 1.89 ± 1.02 | 1.99 ± 1.01 | 1.9 ± 0.99 | 1.79 ± 1.08 | 0.385 |
| Preoperative cholesterol | 184.83 ± 28.49 | 184.34 ± 27.82 | 178.74 ± 27.6 | 177.23 ± 27.3 | 0.028 |
| Body mass index, kg/m² | 23.44 ± 3.07 | 23.98 ± 3.49 | 23.82 ± 3.67 | 24.03 ± 3.57 | 0.101 |
| Systolic blood pressure, mmHg | 124.73 ± 14.99 | 125.08 ± 15.46 | 123.66 ± 16.05 | 122.07 ± 13.3 | 0.438 |
| Free T4, ng/dL † | 1.55 ± 0.26 | 1.44 ± 0.32 | 1.31 ± 0.23 | 1.18 ± 0.23 | <0.001 |
| TSH, mIU/L | 0.02 ± 0 | 0.09 ± 0.06 | 0.84 ± 0.45 | 3.16 ± 0.88 | <0.001 |
| Glucose, mg/dL | 98.92 ± 19.58 | 101.29 ± 24.18 | 100.13 ± 20.71 | 94.7 ± 13.03 | 0.099 |
| Total cholesterol, mg/dL | 181.14 ± 30.79 | 184.47 ± 30.57 | 191.2 ± 32.44 | 193.69 ± 33.65 | <0.001 |
| Total cholesterol, mg/dL | 0.001 | ||||
| <200 | 345 (72.9%) | 269 (68.3%) | 98 (59.8%) | 33 (54.1%) | |
| 200–239 | 113 (23.9%) | 113 (28.7%) | 53 (32.3%) | 23 (37.7%) | |
| ≥240 | 15 (3.2%) | 12 (3.1%) | 13 (7.9%) | 5 (8.2%) | |
| ∆Total cholesterol, mg/dL | −3.69 ± 28.85 | 0.13 ± 28.09 | 12.46 ± 29.84 | 16.46 ± 29.78 | <0.001 |
| Triglyceride, mg/dL | 110.5 ± 56.54 | 114.8 ± 60.05 | 110.1 ± 61.73 | 132.18 ± 70.88 | 0.048 |
| HDL-cholesterol, mg/dL | 51.7 ± 11.72 | 51.2 ± 11.74 | 53.92 ± 11.24 | 51.49 ± 9.55 | 0.084 |
| LDL-cholesterol, mg/dL | 107.34 ± 28.4 | 110.32 ± 28.12 | 115.26 ± 29.44 | 115.76 ± 31.14 | 0.007 |
| LDL-cholesterol, mg/dL | 0.04 | ||||
| <130 | 376 (79.5%) | 304 (77.2%) | 126 (76.8%) | 41 (67.2%) | |
| 130–159 | 81 (17.1%) | 73 (18.5%) | 24 (14.6%) | 14 (23%) | |
| ≥160 | 16 (3.4%) | 17 (4.3%) | 14 (8.5%) | 6 (9.8%) | |
Data are presented as mean ± standard deviation or frequency (%). * Preoperative TSH level data available in 929 patients. † Follow-up T4 level data available in 1009 patients. Abbreviations: HDL, high-density lipoprotein; LDL, low-density lipoprotein; TSH, thyroid-stimulating hormone.